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Caddis, whose side slipped to a fourth defeat in five games with Monday’s 1-0 loss at Radcliffe, said players will be shipped out of Edgar Street to free up cash for new faces.
And he admitted the clear-out would already have begun if it wasn’t a bank holiday.
"I'll move a few out," he said, adding: "I've made my mind up, absolutely.
"It's not a knee-jerk reaction because we lost today, but it was something that's been building up. I don't think we've quite got the reaction from players that we were hoping for.
"There's a lot of players that have been picking up little niggling injuries and, to be brutally honest, we can't carry players like that. We can't carry players that are just going to pick up little injuries here and there."
While not naming players who would be leaving, Caddis said Madou Cisse - the midfielder on a season-long loan from Notts County - was struggling, as were striker Chris Wreh and Eno Nto, and midfielder Kai Williams.
He said: "It's not an excuse at all. I don't want it to look like that. It's me just being honest."
The deflated Scot even questioned some of the players he kept on from last season and, having lost four out of five games, said "it's going to have to change".
Fans have questioned whether the problem lies with coaching as Caddis was ultimately responsible for recruitment, and he didn’t shy away from the criticism.
When this was put to him, he said: "They're absolutely 100% right, so, what do I do? Just try and hide behind an ego and think they'll come good or do I act?
"Some of the recruitment I've brought in hasn't worked."
On potential new signings before Alfreton visit Edgar Street on Saturday, Caddis added: "I'm now at the stage where I don't want to wait. I don't want to just keep waiting and waiting, and waiting to see who's available to come in. I need to act now.
"I need to have funds to go and change the momentum of the season."